NutPuncher Maste-Great Battle

[SoonerClint72]

This is a wonderful log...learning alot! Thank you NP...and inputs by RS, Amozoc and Joe! I hope this continues!

 

[jolter604]

Man i love igf1
Great log man

 

[Nutpuncher]

For my best knowledge (meaning as a fact ...) we're the only one to produce the IGF1 ourselves in a western facility, and have full quality control ability. The products till the last excipients is identical to the original patented IGF1-lr by Repligen Swiss. It can never be compared to any research grade operation, which are actually getting their supply from internet questionable sources in China. I'm sure there are some good suppliers out there, so no disrepect to any source, but u guys get the picture

We carefully chose the dosage of 200mcg per vial - our stability tests confirmed 10 days 100% intact quality after reconstitution in 2-4 Celzius, some users may use a dosage as low as 20-25mcg a day, so we're in the perfect range. a 1000mcg vial simply doesn't make sense, as we all understand.

We still use double then the 100mcg vials which were formerly in the market in order to ensure minimum volume in overseas transportation for our all's safety

^^^^ thats why I've been saying Somedin is the best IGF on the market for regular folks like us...Maybe top level BB competitors (ie Mr Olympia contestants) may have access to something else, but I am confident that its similar and not better unless its authentic pharma grade, but Sciroxx does have checks and balances to ensure you are getting what you paid for...its just regulated by FDA or other countries version of FDA, but not all things can be pharma grade (ie Tren Base lol).

PLEASE NOTE: I made a mistake when I thought Somedin only comes with 1 200mcg via as a kitl, but its actually 5 vials of 200mcg (1kit). So you are getting a total of 1000mcg or 1gram of some Bad Ass IGF-1 lr3.

Is the 1+1 sale still going on?

This is a wonderful log...learning alot! Thank you NP...and inputs by RS, Amozoc and Joe! I hope this continues!

Your welcome. I agree with ya...Great contributions from [MENTION=691]RamboStallone[/MENTION] , [MENTION=695]Amozoc[/MENTION] and da man himself aka [MENTION=698]Sciroxx[/MENTION]

Man i love igf1
Great log man

Thank you..I must agree with you. I am thinking my future will be HGH at around 2.5*-5iu* (depending on which brand I decide to stick with) + 20-50mcg Somedin IGF-1 lr3 however long it takes me to consume 2 vials and 2 weeks off IGF and repeat.

*depends on your medical history, goals, choice of HGH brand (generic or pharma) as very few generics are overdosed (1 specific brand is intentionally overdosed, most generics are underdosed and some generics are dosed appropriately, and I guess (aka my bro-science) genetics because some can use less and and some has to use more to to get similar results... Another factor that may be due to someone who has the mindset of "I WILL NOT get out worked" and diet on point or someone that inconsistently workouts with no diet restrictions but ironically on HIGH doses on PEDs)



Can someone please comment on consume 2 vials and 2 weeks off IGF and repeat.? Whats your thoughts on that protocol?

 

[Sciroxx]

Sure we keep running the BOGO special deal for HCU members !

Tks for the honest feedback

 

[Sciroxx]

Regarding the 2+2 protocl - first time I hear of it, but I can see the logic behind it, the lr3 version have a very long half life - here is some scientific literature about it - https://www.ncbi.nlm.nih.gov/pubmed/18567600) - The actions of IGF-I in vivo are modulated by IGF binding proteins (IGFBPs), which generally act to inhibit IGF-I signalling. the analogue of IGF-I (LR IGF-I) has a significantly reduced binding affinity for IGFBPs. In simple words most of the IGF1 in the body is bounded to binding proteins (same as u probably know is testosterone and other hormones) which makes it non active, the, the new configuration in the Somedin helps it travel in its active form in the serum and activates its receptors much much more effectively.
So the Somedin (lr3 version) constantly attacks the receptors, hence using on-off protocol may optimize it's effect and enable upregulation of the IGF1 receptors
What may be more interesting is using for instance 50mcg of lr3 per day with 50mcg of IGF1-DES preworkout for 2 weeks, following with 2 weeks on 100mcg DES per day by itself (the DES has much shorter half life of 20 minutes compared to more then 20 hours of the lr3, but the DES has the highest affinity to the receptor, meaning it'll occupy any receptor in sight but won't travel long in the circulation as it diminishs swiftly, thus his main effect is local at the injection site) so it's much less abusive on the whole systemic receptors. After 4 weeks I would take 2 weeks of and continue the cycle

 

[RamboStallone]

In my opinion, I have not seen any real evidence suggesting desensitization or any such sort with prolonged igf1 usage whether LR3 or DES. I'm not convinced there is a reason to take a break. If you are still reaping benefits up until that last day, I would stay on especially if using reasonable doses such as 20-40mcgs a day. If you start feeling the desensitization occurring, i.e. effects and results have diminished, then a proper break would be needed. It would be nice to see if you ever hit that point on somedin though. We could learn something new from this.

 

[Nutpuncher]

Sure we keep running the BOGO special deal for HCU members !

Tks for the honest feedback

Awesome. I am seriously debating on BOGO IGF....now I just need to come up with 20000 pennies, but I don't think BTC takes pennies.

Regarding the 2+2 protocl - first time I hear of it, but I can see the logic behind it, the lr3 version have a very long half life - here is some scientific literature about it - https://www.ncbi.nlm.nih.gov/pubmed/18567600) - The actions of IGF-I in vivo are modulated by IGF binding proteins (IGFBPs), which generally act to inhibit IGF-I signalling. the analogue of IGF-I (LR IGF-I) has a significantly reduced binding affinity for IGFBPs. In simple words most of the IGF1 in the body is bounded to binding proteins (same as u probably know is testosterone and other hormones) which makes it non active, the, the new configuration in the Somedin helps it travel in its active form in the serum and activates its receptors much much more effectively.
So the Somedin (lr3 version) constantly attacks the receptors, hence using on-off protocol may optimize it's effect and enable up regulation of the IGF1 receptors
What may be more interesting is using for instance 50mcg of lr3 per day with 50mcg of IGF1-DES preworkout for 2 weeks, following with 2 weeks on 100mcg DES per day by itself (the DES has much shorter half life of 20 minutes compared to more then 20 hours of the lr3, but the DES has the highest affinity to the receptor, meaning it'll occupy any receptor in sight but won't travel long in the circulation as it diminish swiftly, thus his main effect is local at the injection site) so it's much less abusive on the whole systemic receptors. After 4 weeks I would take 2 weeks of and continue the cycle

Good to know, thank you. I like what may be more interesting. I may have to grab some IGF-1 DES and more Somedin and try that out.

In my opinion, I have not seen any real evidence suggesting desensitization or any such sort with prolonged igf1 usage whether LR3 or DES. I'm not convinced there is a reason to take a break. If you are still reaping benefits up until that last day, I would stay on especially if using reasonable doses such as 20-40mcgs a day. If you start feeling the desensitization occurring, i.e. effects and results have diminished, then a proper break would be needed. It would be nice to see if you ever hit that point on somedin though. We could learn something new from this.

I'd love to try your experiment, but its an expensive experiment as who knows how long before I notice desensitization and more important, how will I know desensitization has occurred.

 

[Sciroxx]

Ok - I will offer some extra gifts and best deals to anyone who likes to make a log, just contact me if have any interest,

I'm especially interested in the DES which is a new novel products for us

 

[Nutpuncher]

Ok - I will offer some extra gifts and best deals to anyone who likes to make a log, just contact me if have any interest,

I'm especially interested in the DES which is a new novel products for us

I'll be in touch..........

 

[RamboStallone]

Awesome. I am seriously debating on BOGO IGF....now I just need to come up with 20000 pennies, but I don't think BTC takes pennies.




Good to know, thank you. I like what may be more interesting. I may have to grab some IGF-1 DES and more Somedin and try that out.



I'd love to try your experiment, but its an expensive experiment as who knows how long before I notice desensitization and more important, how will I know desensitization has occurred.

What I meant was you don't need to take the 2 weeks off in between if you don't want to, that's all. And yea obviously if you don't take the break you will use more lol so yea you will use more in less time so it will be more costly. The idea of breaks was to avoid desensitization and down regulation of receptors but recent data on both AAS and growth factors have shown up regulation with increased hormones and muscle mass. I was just wondering if one were to use Somedin at a low dose of 20mcgs for months on end, would they ever really experience any desensitization and/or down regulation? You would notice this if it stops working. Something to keep in mind during your run, will your last dose still feel as effective as your first, etc. No need to change what you are doing, not my intention. Just would like that feedback so we can learn from it.

Thanks bro!!

 

[Nutpuncher]

What I meant was you don't need to take the 2 weeks off in between if you don't want to, that's all. And yea obviously if you don't take the break you will use more lol so yea you will use more in less time so it will be more costly. The idea of breaks was to avoid desensitization and down regulation of receptors but recent data on both AAS and growth factors have shown up regulation with increased hormones and muscle mass. I was just wondering if one were to use Somedin at a low dose of 20mcgs for months on end, would they ever really experience any desensitization and/or down regulation? You would notice this if it stops working. Something to keep in mind during your run, will your last dose still feel as effective as your first, etc. No need to change what you are doing, not my intention. Just would like that feedback so we can learn from it.

Thanks bro!!

That is a great question.... My bro-science answer which is my opinion which I based on nothing other than countless hours of research....... NO, you will not desensitization and/or down regulation as long as you keep your dose low (ie 20mcg). The reason for my answer is because our body does an amazing job of adapting to changes. HOWEVER, 20mcg may not be enough couple months down the road due our amazing body's ability to adapt and uses it as the new norm.


There is one way to find out..........try it until your last dose doesn't feel like your first dose, but is that desensitization and/or down regulation or is that your body needs more as your tolerance increases.

 

[Sciroxx]

May some one refer me to a link to some authority that may explain/recommend on the 20mcg notion (but Dave palumbo...)

 

[RamboStallone]

May some one refer me to a link to some authority that may explain/recommend on the 20mcg notion (but Dave palumbo...)

It's based on anecdotal evidence, that is all. Do you feel more is needed? I'm not sure what doses they used in any of the studies.

 

[Sciroxx]

I certainly don't have enough experience with low dosage to be honest.

I'm familiar with the clinical work with increlex, although it's different product, which from start requires like 50 higher dosages as it contains regular IGF1, and not the lr3 version, when applied to chidlren who suffer from growth deficit the dosages are equivalent to 300-500mcg of the lr3.

Possible that along with GH and AAS a maintenance dosage of 20mcg on the lr3 may have benefits, especially concerning balancing the hyperglycemic effect of the GH, but by itself I believe 20mcg is too low to achieve anabolic effect

 

[Nutpuncher]

My Sciroxx Somedin IGF-1 lr3 experience & Maste-Great Battle & tentative schedule

May some one refer me to a link to some authority that may explain/recommend on the 20mcg notion (but Dave palumbo...)

I am using 20-25mcg because that is all that I need to get ravishing pumps and my diet has not been good since Aug 13 (day 1 of my vacation), but this morning I woke up to a nice 6 pack and obliques. I get the most vascular so far shortly after I started Somedin.

I will take you up on that experiment that you mentioned few post above, but money is tight right now....so hopefully in couple weeks we can work something out.

Also, Mastodex is not like the Mast Prop that I've tried before (not naming because not from sponsor here). I can already see difference in mirror. I am the most vascular ever now a days, but I don't walk around like that. It takes either eating carbs when I am depleted with only lifting chopsticks (not weights) or during workout. I do feel on Mastodex: Gym aggression is very noticeable, sex drive increased, muscles feels chiseled rather than a blob if that makes sense. I am so happy that my Mastodex run isn't over yet, but I am also looking forward to [MENTION=699]Kronos[/MENTION] , [MENTION=816]dyel[/MENTION] Mast Prop and as a surprise, the last 2 mast prop will be from raw powder by [MENTION=701]crazysteriod[/MENTION] & [MENTION=57]Anny[/MENTION]

Please feel free to comment on my tentative compound schedule.

 

[Sciroxx]

I see correctly on the log bro ? the last feedback on the masteron is on Sciroxx ?

 

[Nutpuncher]

I see correctly on the log bro ? the last feedback on the masteron is on Sciroxx ?

You are correct.

 

[RamboStallone]

Sciroxx, I'll have to dig into it more. The data on increlex is irrelevant to a degree, in my opinion, since des and lr3 are a different chain. I'll see what I can find and post back here.

NP, I'd personally drop the deca and add more test or a small dose of tren. A small dose of tren goes a long way, I'm using 25-30mgs a day with good results. It was for damage control after a month of shit that prevented proper training and diet. But I'm not a big fan of deca really.

Either way good luck, anabolics are anabolics, they all work.

 

[CrazySteroids]

Hi Nutpuncher,thanks for your feedback,Keep us updated with your progress bro.Can't wait CrazySteroids quality result.
==HARDCORE[[

 

[Nutpuncher]

Sciroxx, I'll have to dig into it more. The data on increlex is irrelevant to a degree, in my opinion, since des and lr3 are a different chain. I'll see what I can find and post back here.

NP, I'd personally drop the deca and add more test or a small dose of tren. A small dose of tren goes a long way, I'm using 25-30mgs a day with good results. It was for damage control after a month of shit that prevented proper training and diet. But I'm not a big fan of deca really.

Either way good luck, anabolics are anabolics, they all work.

I love Nandrolone for joints and will be on low dose DECA going forward as I don't have TRT bloods anymore. Last Tren usage gave me bad acne on my jawline and back and some on my chest and traditional tren sides weren't fun. But small dose as you mentioned might be small enough to mitigate sides. And I agree with you, small dose of Tren still works. When sides were too uncomfortable, I lowered Tren from 525mg/week down to 350mg/week and finally down to 150mg/week and kept it there for remaining weeks (can't remember exactly).

I like your tren advice so much that I will 25mg to each pin which will be 3x/week totaling 75mg/week....I just happen to be brewing some CompTren, but its for a friend..but I am sure he won't mind if I keep one for myself



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