What are the SLU-PP-332 clinic trials results

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Recently, SLU-PP-332 powder is getting popular on the market for weight loss, bodybuilding etc. And here is its clinic trals, pls help to check:

SLU-PP-332 is still being developed under Burris’s laboratory at Washington University in St. Louis. It was developed as a exercise mimetic to mimic the effects of physical exercise on the body without requiring physical activity. The early trials are primarily in animal models and have shown promising results including:

Significant Weight Loss and Fat Reduction: Without changing the food intake and activity levels, researchers treat one group obese mice with SLU-PP-332, observed there was about 12% reduction in body weight and significant fat accumulation. The drug show the ability to boost the body’s metabolism, making the body to exercise more, which leads to faster fat burning and greater energy expenditure.

Increased Endurance: In one study, researchers observed that SLU-PP-332 can increase endurance as well. This drug helped mice improve their aerobic capacity to increase endurance, helping them run 70% and 45% further than untreated mice.

Metabolic Impact: Mice treated with SLU-PP-332 can see their whole body metabolism turns to use fatty acids as an energy source, which is very similar to what happens during exercise or fasting. This demonstrated SLU-PP-332 has potential to maintain or even increase muscle mass during weight loss. This is very meaningful for age-related muscle loss and patients with metabolic diseases.

Heart Health: In other work the Burris lab is about to publish, SLU-PP-332 can strengthen the heart muscle in mice to treat heart failure.

 

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Potential Benefits of SLU-PP-332​

The study on SLU-PP-332 is ongoing; nevertheless, some existing research has demonstrated its potential benefits.

①Alleviate Metabolic Syndrome

SLU-PP-332 possesses exercise-mimicking action and significantly reduced obesity and enhanced insulin sensitivity in a rat model of obesity and metabolic syndrome, suggesting that it could be a viable treatment for both conditions.

Source: https://pubmed.ncbi.nlm.nih.gov/37739806/

②Enhance Exercise Capacity

SLU-PP-332 increases cellular respiration and mitochondrial activity in skeletal muscle cell lines. It also produces an acute aerobic exercise gene program unique to ERRα, which improves exercise endurance in mice.

Source: https://pubmed.ncbi.nlm.nih.gov/36988910/

③Improve Heart Failure

ERRγ is a major mediator of ERR agonism-induced transcriptional regulation and cardioprotection and clearly shows targeting specificity. In experiments in mice, SLU-PP-332 significantly improved ejection fraction, improved fibrosis, and increased survival associated with HF caused by pressure overload without affecting cardiac hypertrophy.

Source: https://pubmed.ncbi.nlm.nih.gov/37961903/

④Reverse Mitochondrial Function and Inflammation in the Aging Kidney

ERR is reduced in both aging human and mouse kidneys, whereas ERR remains unchanged in aging mice subjected to lifelong caloric restriction (CR). Eight weeks of treatment with SLU-PP-332 reversed age-related increases in albuminuria, podocyte loss, mitochondrial dysfunction, and inflammatory cytokines.

Source: https://pubmed.ncbi.nlm.nih.gov/37717940/