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Ora-plus suspending vehicle for liquid orals

Mountain-Man

Veteran
Mar 17, 2016
726
5
Thought you guys might like this over grain alcohol
Quote
Ora-Plus is a unique suspending vehicle used to simplify the process involved in the
extemporaneous compounding of oral suspensions. Medicated powder can be incorpo-
rated into Ora-Plus to form elegant, uniform and physically stable suspensions.

Applications
Ora-Plus will retain its suspending properties when diluted up to
50% with water, flavoring agents, syrups or alcohol.
....
Ora-Plus is an aqueous-based vehicle consisting of a synergistic
blend of suspending agents that have a high degree of colloidal
activity. The suspending agents form a structured, gel-like matrix
which suspend particles and allow for little settling. Ora-Plus is
buffered to a slightly acidic pH to help reduce degradation of
medicinal agents through oxidation. An anti-foam agent is incor-
porated into Ora-Plus to allow for vigorous shaking with minimal foam.

Ingredients
Purified water, microcrystalline cellulose, carboxymethyl-
cellulose sodium, xanthan gum, carrageenan, calcium sul-
fate, trisodium phosphate, citric acid and sodium phosphate
as buffers, dimethicone antifoam emulsion. Preserved with
methylparaben and potassium sorbate.
....
Contraindications
Ora-Plus is contraindicated in persons who have shown hypersensitivity to any of the listed
ingredients.
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General Directions For Compounding ORA-SWEET*/ORA-PLUS Suspensions
[Ora-Sweet is an optional flavoring]

• Calculate the total amount of active ingredient and volume of solution needed to
create a suspension of the proper concentration. (Calculations are provided in the
examples above.) It may be wise to add approximately 10% overage for compound-
ing losses.
• Crush tablets with a mortar and pestle to a fine powder. If the compound is
already in the powder form, use the mortar and pestle to smooth out the powder.
• Add a small amount of Ora-Plus and triturate to a thick, smooth paste. Add the
remainder of Ora-Plus by geometric dilution. The amount of Ora-Plus should be
50% of the total solution.
• Bring the suspension to a final volume using Ora-Sweet*. Mix briefly with a mor-
tar and pestle until a uniform suspension is formed. [Ora-Sweet is an optional flavoring]
• Dispense in a tight, light resistant amber bottle with appropriate labeling.
• Label with an expiration date. If the stability of the medication in an oral suspen-
sion or syrup is unknown, conservative dating is suggested.
•Depending on the medicinal agent used, label containers "Shake Well Before
Using," "Protect From Light," and "Keep Refrigerated."
....
 
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