Cetilistat vs Orlistat

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(1)Similarities in the mechanism of action​

Cetilistat and Orlistat share a similar mechanism of action, both targeting and inhibiting gastrointestinal lipases to reduce fat absorption and promote weight loss.

(2)Differences in chemical structure and properties​

While their mechanisms of action are similar, cetilistat and Orlistat differ in their chemical structures, leading to differences in their pharmacokinetic properties and side-effect profiles.

(3)Comparing efficacy and weight loss results​

Clinical trials have demonstrated that cetilistat is comparable to Orlistat in terms of weight loss efficacy. Both medications can help patients achieve significant weight loss when used as part of a comprehensive obesity management program.

(4)Tolerability and side effect profile comparison​

Cetilistat generally has a more favorable tolerability profile compared to Orlistat. Patients taking cetilistat are less likely to experience gastrointestinal side effects, making it a more attractive option for those who have difficulty tolerating Orlistat.