Anabolic Steroids and Cialis for building MUSCLE?!?!

[Seth(The Spartan)]

Been hearing that cialis and viagra are good for building muscle because they push bloodflow out into systemic circulation (Muscular system), this makes sense being that there are studies on it increasing performance in humans.
Besides, better bloodflow=better nutrient support=better growth.

Any body weigh in on this?!


Found this video on it interesting!

https://www.youtube.com/watch?v=J1I9rgFC_D4

 

[MotorCityMuscleMachine]

Been hearing that cialis and viagra are good for building muscle because they push bloodflow out into systemic circulation (Muscular system), this makes sense being that there are studies on it increasing performance in humans.
Besides, better bloodflow=better nutrient support=better growth.

Any body weigh in on this?!


Found this video on it interesting!

https://www.youtube.com/watch?v=J1I9rgFC_D4

Interesting.., learn something new. . Hmm. I do like the oumps with Cialis, can't stand V tho..

Get flush, head ache, allergy type feeling , stuffy, ears get flame red.

 

[Anon44]

Interesting.., learn something new. . Hmm. I do like the oumps with Cialis, can't stand V tho..

Get flush, head ache, allergy type feeling , stuffy, ears get flame red.

I get the same reaction from it. It does it's job well but the sides aren't worth the benefit.

 

[MotorCityMuscleMachine]

I get the same reaction from it. It does it's job well but the sides aren't worth the benefit.

Must be a damn D-Town thang...! Lol..!

Yeah, never could take em' , may try again in a very miniscule AMT.and along with Cialis, but if it bothers me the same way, I'm ditching it altogether.

MotorCity

 

[thebiggening]

I get the same reaction from it. It does it's job well but the sides aren't worth the benefit.

totally agree. ill have to watch this later

 

[Roc]

Used to get the sides, I take 10mg daily and the sides went away, on 20mg I was a mess!!

 

[Kins]

I take 25mg per day when I have it. I don't get sides with either Viagra or Cialis.

 

[Anon44]

Yeah for me the Viagra makes me real stuffy with a headache. It definitely gets me going to do the wife.... but the headache and not being able to breathe suck.

My buddy gave me a 100 mg Viagra on my wedding night and my wife told me to never take one again. lol I killed it!!!!

 

[dc81]

Cialis always gives me a headache. I only take it on pct because I get in my own head and mess up my libido.😖

dc.

 

[tmac3t]

Been hearing that cialis and viagra are good for building muscle because they push bloodflow out into systemic circulation (Muscular system), this makes sense being that there are studies on it increasing performance in humans.
Besides, better bloodflow=better nutrient support=better growth.

Any body weigh in on this?!


Found this video on it interesting!

https://www.youtube.com/watch?v=J1I9rgFC_D4

this is copy and paste but was a good read and i have been doing my own research on myself and seems to be working will keep researching

(from aka the roid )
I've been advocating the use of Cialis/Tadalafil for years, for reasons going far beyond its use to improve erection quality. Improved body composition, blood pressure control, anabolism, insulin signalling and nutrients delivery to skeletal muscles, to name a few.

Here is some food for thought

Effect of phosphodiesterase inhibition on insulin resistance in obese individuals.

Ho JE1, Arora P2, Walford GA3, Ghorbani A4, Guanaga DP5, Dhakal BP6, Nathan DI7, Buys ES7, Florez JC8, Newton-Cheh C9, Lewis GD6, Wang TJ10.
Author information
Abstract
BACKGROUND:
Obesity is associated with cardiometabolic disease, including insulin resistance (IR) and diabetes. Cyclic guanosine monophosphate (cGMP) signaling affects energy balance, IR, and glucose metabolism in experimental models. We sought to examine effects of phosphodiesterase-5 inhibition with tadalafil on IR in a pilot study of obese nondiabetic individuals.
METHODS AND RESULTS:
We conducted a randomized, double-blinded, placebo-controlled trial of adults age 18 to 50 years with obesity and elevated fasting insulin levels (≥10 μU/mL). Participants were randomized to tadalafil 20 mg daily or placebo for 3 months. Oral glucose tolerance tests were performed, and the effect of tadalafil on IR was examined. A total of 53 participants (mean age, 33 years; body mass index [BMI], 38 kg/m(2)) were analyzed, 25 randomized to tadalafil and 28 to placebo. In the overall sample, measures of IR did not differ between tadalafil and placebo groups at 3 months. However, in individuals with severe obesity (BMI ≥36.2 kg/m(2)), tadalafil use was associated with improved IR (homeostatic model assessment for IR), compared to placebo (P=0.02, respectively). Furthermore, one measure of β-cell compensation for IR (oral disposition index) improved with tadalafil in the overall sample (P=0.009) and in the subgroup with severe obesity (P=0.01).
CONCLUSION:
Results of this pilot study did not show improvements in IR with tadalafil, compared to placebo. However, tadalafil may have favorable effects on β-cell compensation, particularly in individuals with severe obesity. Future studies evaluating the potential metabolic benefits of cGMP modulation in obesity are warranted.



Insulin-like effect of the phosphodiesterase type 5 inhibitor tadalafil onto male human skeletal muscle cells.

Crescioli C1, Sturli N, Sottili M, Bonini P, Lenzi A, Di Luigi L.
Author information
Abstract
BACKGROUND:
Phosphodiesterase type 5 inhibitors (PDE5i), widely used to treat male erectile dysfunction, seem to counteract insulin resistance (IR) in animals and humans. IR, primarily manifest in peripheral tissues and particularly in skeletal muscle, is due to impaired insulin signal transduction. Investigators have been focusing onto intracellular defects responsible for IR to identify suitable pharmacological tools targeted toward the specific defects. Albeit some effects of PDE5i have been reported onto animal muscular tissues or cells, whether and how they might affect metabolic processes directly in human skeletal muscle still remains unclear.
AIM:
We aimed to investigate in human fetal skeletal muscle cells (Hfsmc) the effect of tadalafil, one of PDE5i, onto some intracellular factors involved in response to insulin, such as ras-raf mitogen activated protein kinase (MAPK), phosphatidylinositol 3-kinase/protein kinase B (PKB/Akt), glycogen synthase kinase 3β (GSK-3β), and the transcriptional factor c-Myc; proliferation rate; lactate (lact) and free fatty acid (ffa) release; activity of citrate synthase (CS) and succinate dehydrogenase (SDH), both enzymes of Kreb's cycle; PDE5 gene expression.
MATERIALS AND METHODS:
Western blot analysis, enzyme-linked immunosorbent assay, enzymatic assays, cell count, MTT assay and Real Time PCR were performed in Hfsmc with and without tadalafil.
RESULTS:
In Hfsmc tadalafil affected the insulin-related intracellular cascade, by increasing MAPK, PKB/Akt, GSK-3β phosphorylation and c-Myc expression. ffa release and CS activity also significantly increased, with no changes in SDH activity and lact release.
CONCLUSIONS:
Tadalafil, like insulin, targeted part of the machinery dedicated to energy management and metabolic control in human skeletal muscle cells.


Tadalafil improves lean mass and endothelial function in nonobese men with mild ED/LUTS: in vivo and in vitro characterization.

Aversa A1, Fittipaldi S2, Francomano D3, Bimonte VM4, Greco EA3,5, Crescioli C4, Di Luigi L4, Lenzi A3, Migliaccio S4.
Author information
Abstract
PURPOSE:
Phosphodiesterase type-5 inhibitor administration in diabetic men with erectile dysfunction (ED) is associated with reduced waist circumference. We evaluated potential effects of daily tadalafil administration on body composition and investigated its possible mechanism(s) of action in C2C12 skeletal muscle cells in vitro.
METHODS:
Forty-three men on stable caloric intake (mean age 48.5 ± 7; BMI 25.5 ± 0.9 kg/m2) complaining mild ED and/or low urinary tract symptoms (LUTS) were randomly assigned to receive tadalafil (TAD) 5 mg/daily (once-a-day=OAD-TAD; n = 23) or 20 mg on-demand (on-demand=OD-TAD; n = 20) for 2 months. Primary outcomes were variations of body composition measured by Dual-energy X-ray absorptiometry; secondary outcomes were ED/LUTS questionnaire scores along with hormone (testosterone, estradiol, insulin) and endothelial function (Endopat2000) variations.
RESULTS:
OAD-TAD increased abdominal lean mass (p < 0.01) that returned to baseline after 2 months withdrawal. LUTS scores improved (p<0.01) in OD-TAD while ED scores improved (p < 0.01) in both groups. We found significant improvements in endothelial function (p < 0.05) that directly correlated with serum insulin (p < 0.01; r = 0.3641) and inversely correlated with estradiol levels (p < 0.01; r = 0.3655) even when corrected for potential confounders. Exposure of C2C12 cells upon increasing tadalafil concentrations (10-7 to 10-6 M) increased total androgen receptor mRNA and protein expression as well as myogenin protein expression after 24 and 72 h (2.8 ± 0.4-fold and 1.4 ± 0.02-fold vs. control, respectively, p < 0.05).
CONCLUSIONS:
Daily tadalafil improved lean mass content in non-obese men probably via enhanced insulin secretion, estradiol reduction, and improvement of endothelial function in vivo. The in vitro increased myogenin and androgen receptor protein expression in skeletal muscle cells suggests a translational action of phosphodiesterase type-5 on this receptor.

 

[spyderwebb]

Been hearing that cialis and viagra are good for building muscle because they push bloodflow out into systemic circulation (Muscular system), this makes sense being that there are studies on it increasing performance in humans.
Besides, better bloodflow=better nutrient support=better growth.

Any body weigh in on this?!


Found this video on it interesting!

https://www.youtube.com/watch?v=J1I9rgFC_D4

Idk man low blood pressure always makes me feel like crap... calice clogs me up like no tomorrow... like as in my cinus passage can't breathe eyes water hate it...


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[gesus]

i take cialis everyday @ 10 mg about an hr before my workouts..it's my understanding that cialis helps with nitrogen retention which is a + for muscle, helps with prostate swelling that naturally comes from taking an androgen and frees up test being bound by sex hormone so ups your free test levels as well.

 

[bigsjunk]

i take cialis everyday @ 10 mg about an hr before my workouts..it's my understanding that cialis helps with nitrogen retention which is a + for muscle, helps with prostate swelling that naturally comes from taking an androgen and frees up test being bound by sex hormone so ups your free test levels as well.

What this guy said ^. Always take it before I work out but 15mg. Careful if you are doing supersets as the pump is just about as painful as Dbol pumps.

 

[spyderwebb]

Cialis pugs me up makes my nose clog up bad to the point I can't breathe


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[gesus]

yes, ive noticed the pumps to get pretty crazy right now im running some anadrol and chest pump was actually painful last night..I do tend to "cycle" the cialis ill go on 2 wks off for 1 wk because I feel that you can build a "tolerance" to it being a pd5e inhibitor

 

[Kins]

yes, ive noticed the pumps to get pretty crazy right now im running some anadrol and chest pump was actually painful last night..I do tend to "cycle" the cialis ill go on 2 wks off for 1 wk because I feel that you can build a "tolerance" to it being a pd5e inhibitor

Yeah I can take 25mg-40mg per day now. I'm on a break from it though, but only because I only have 2 tablets left. When I first tried it several years ago I got low bp side effects. No more though.