Ozempic, Mounjaro, Retatrutide + Steroids/HGH – Smart Strategy or Bad Idea?

[sciroxxonline]

A lot of guys lately are asking:

“I’m on Mounjaro or Ozempic (and maybe Retatrutide soon) – should I add steroids or HGH so I don’t lose muscle?”

I wrote an article that answers that in detail:
👉 Should Mounjaro, Ozempic, or Retatrutide Be Combined with Steroids and HGH?


Main points:

• GLP-1 / GIP / triple agonist drugs (Ozempic, Mounjaro, Retatrutide) are insanely effective for weight loss, largely by slashing appetite and calories.
• Along with fat, you do lose lean mass, and that’s a big issue for strength, performance and long-term health.

So people start thinking about:

🔹 Adding steroids​

• Anabolics are extremely effective against muscle loss in a calorie deficit.
• There’s no direct pharmacologic clash with GLP-1 drugs—they actually complement each other in terms of body composition.
• But don't forget to consider:
  • Higher cardio-metabolic risk
  • Liver and lipid stress
  • HPTA and fertility suppression

🔹 Adding HGH​

• HGH burns fat and supports lean mass, but worsens glucose and insulin sensitivity.
• GLP-1 / GIP drugs do the opposite—improve insulin sensitivity and glycemic control.
• On paper: huge recomposition synergy.
• In reality: no real safety data, overlapping side effects, and long-term risk is unknown.

🔹 Retatrutide​

• Even more potent weight-loss triple agonist.
• Makes lean-mass preservation more important, but gives us zero guidance on safe stacking with steroids or HGH.

I also outline what you can do without drugs:

• Heavy training, high protein, sane deficit, and only considering TRT/GH for real deficiencies under medical supervision.

Full article is here if you’re playing with these meds and care about muscle, not just the scale:


👉 Should Mounjaro, Ozempic, or Retatrutide Be Combined with Steroids and HGH?